Career Opportunities
Infinity Pharmaceuticals, Inc. is an innovative cancer drug discovery and development company that is seeking to leverage its strength in small molecule drug technologies to discover, develop, and deliver to patients first-in-class or best-in-class medicines for the treatment of cancer and related conditions.
Associate Director, Drug Metabolism & Pharmacokinetics - Cambridge, MA
Position Responsibilities:
The Associate Director, Drug Metabolism & Pharmacokinetics will be responsible for overseeing the efforts directed at understanding the metabolism and biological fate of our drug candidates to support our global drug discovery and development strategies. This includes managing and hands-on contributions to the development of in vitro ADME assays (i.e. CYP inhibition, CYP induction, reactive metabolite profiling) as well as the translation of these observations into an understanding of in vivo metabolic fate. The individual will be responsible for leading our strategy in deciphering the in vivo biotransformations of our drug candidates, from pre-clinical animal models through the clinic. The selected individual will work closely with other scientists and disciplines (pharmacology, chemistry, pharmaceutical development, toxicology and clinical) to analyze and interpret the resulting biotransformation and metabolism data and plan the path forward. The candidate will also be expected to work independently while effectively mentoring and supporting the development of team members.
Position Requirements
- Degree in Chemistry, Analytical Chemistry, Biochemistry, Biology, Pharmacology or related field; Ph.D. with a minimum of 8 years industry experience.
- Experience with leading the drug metabolism studies required to support drug candidate selection, IND enabling studies and first-in-man investigations.
- Must have extensive experience in small molecule structural elucidation and thorough understanding of biotransformation pathways and processes.
- Hands-on experience with hepatocytes is strongly desired.
- Strong analytical skills including methods development as well as operation and maintenance of analytical hardware (HPLC, mass spectrometers) required, as well as the use of associated data processing software (e.g. Analyst, MetaboliteID).
- Strong interpersonal and leadership skills; passion for staff development and mentorship.
- Experience with outsourcing studies and evaluating external reports from contract research organizations is desirable.
- A sound understanding of pharmacokinetics and drug disposition is desired.
- Must have good writing and communication skills, attention to detail, and strong problem-solving skills, as well as the ability to work in a multidisciplinary team environment and present their work at departmental meetings.
Infinity offers an outstanding benefits package and is a EOE. Interested applicants can apply on-line at www.infi.com.
